“Inter and Intra-Individual Variability of Drug Efficacy, Toxicity and Disposition”
Personalized medicine has been a critical issue in the creation and proper use of drugs. Efficacy and toxicity of drugs are affected by changes in pharmacokinetic and/or pharmacodynamics factors, including concomitant medication and pathophysiological state, genetic variation, and epigenetic changes in certain genes encoding membrane transporters and metabolic enzymes. Our research is directed to clarify the mechanisms of inter- and intra-individual variability of efficacy, toxicity and disposition of drug and to improve QOL of patients.
Additionally, we conduct the study of data science research, pharmacy innovation, and pharmacist resource development to achieve sustainability of medical and social health system in the super aged society.
