Main Research Theme
- Development of novel reactions and reagents for applications in the life sciences
- Design of selective functional group transformation methods to elucidate biomolecular functions
- Creation of high-performance luminescent molecules for functional expression in cellular environments
Outlines of Research
The Laboratory of Bioorganic Molecular Chemistry seeks to understand and control biological phenomena at the molecular level using an organic chemistry approach. Our core philosophy is to “design molecules ourselves, synthesise them reliably, and use them to create new value.” Guided by this principle, we create unique molecules that contribute to the life sciences.
We are particularly focused on the development and application of hybrid molecules—structures that integrate multiple functional units to generate novel properties and behaviors. By strategically assembling these units within a single molecular framework and orchestrating their interactions, we aim to engineer functions that do not occur in nature.
We develop molecules for use in the life sciences, drawing inspiration from natural products, synthetic functional compounds, fluorescent dyes, chemical reagents, and molecular inhibitors. Our research themes span a broad spectrum, including:
- The development of site-selective molecular modification methods using highly reactive species such as strained molecules and radicals;
- The design of inhibitors targeting membrane proteins, particularly ABC transporters implicated in multidrug resistance;
- The creation of near-infrared luminescent probes and chiral luminescent molecules that exhibit circularly polarised luminescence (CPL) and are functional in cellular environments.
We hope that students will experience the excitement of advancing life science research by designing entirely new molecules with unprecedented functions. Alongside hands-on research, we offer abundant opportunities for conference presentations and collaborative projects, helping students build a versatile skill set for their future careers.
We warmly welcome applications from individuals who are passionate about organic chemistry and eager to explore the frontiers of molecular science.
