- Mechanistic analysis of human nucleotide excision repair (NER) using a chemical biology approach
- Development of anticancer drugs targeting the DDR network
- Mechanistic analysis of the formation and repair of secondary DNA damage induced by abortive NER in quiescent cells
Our cells are equipped with a sophisticated network of DNA-damage response (DDR) including various kinds of DNA repair and DNA-damage tolerance systems. In our lab, we have been focusing on the mechanistic analyses of one of DNA repair systems, nucleotide excision repair (NER), and NER-related reactions in human cells. The NER is responsible for repairing a variety of helix-distorting DNA lesions induced by environmental UV or bulky chemicals, using a complex step-by-step mechanism with a number of proteins. From our studies, we are aiming to contribute to cancer prevention as well as cancer therapy targeting the DDR network.
