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27. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.
Nakamura T, Miyabe H, Hyodo M, Sato Y, Hayakawa Y, Harashima H*.
J Control Release 216: 149-157 (2015). -
26. The intracellular pharmacodynamics of siRNA is responsible for the low gene silencing activity of siRNA-loaded nanoparticles in dendritic cells.
Nakamura T, Fujiwara Y, Warashina S, Harashima H*.
Int J Pharm 494: 271-277 (2015). -
25. Influence of endosomal escape and degradation of α-galactosylceramide loaded liposomes on CD1d antigen presentation.
Nakamura T, Kuroi M, Harashima H*.
Mol Pharm 12: 2791-2799 (2015).DOI : 10.1021/mp500704e.
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24. A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant.
Miura N, Shaheen SM, Akita H*, Nakamura T, Harashima H.
Nucleic Acids Res 43: 1317-1331 (2015).DOI : 10.1093/nar/gkv008.
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23. Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model.
Nakamura T, Fukiage M, Suzuki Y, Yano I, Miyazaki J, Nishiyama H, Akaza H, Harashima H*.
J Control Release 196: 161-167 (2014). -
22. Octaarginine-modified liposomes enhance cross-presentation by promoting the C-terminal trimming of antigen peptide.
Nakamura T, Ono K, Suzuki Y, Moriguchi R, Kogure K, Harashima H*.
Mol Pharm 11: 2787-2795 (2014).DOI : 10.1021/mp500147y.
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21. A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy.
Miyabe H, Hyodo M, Nakamura T, Sato Y, Hayakawa Y, Harashima H*.
J Control Release 184: 20-27 (2014). -
20. Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, mincle.
Hattori Y, Morita D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S*, Sugita M*.
J Biol Chem 289: 15405-15412 (2014).DOI : 10.1074/jbc.M114.566489.
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19. Nanoparticulation of BCG-CWS for application to bladder cancer therapy.
Nakamura T, Fukiage M, Higuchi M, Nakaya A, Yano I, Miyazaki J, Nishiyama H, Akaza H, Ito T, Hosokawa H, Nakayama T, Harashima H*.
J Control Release 176: 44-53 (2014). -
18. Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.
Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, Igarashi T, Harashima H, Sugita M*.
Biochem Biophys Res Commun 441: 108-113 (2013).