研究業績

• Negishi, T., Xing, F., Koike, R., Iwasaki, M., Wakasugi, M., and Matsunaga, T. (2023). UVA causes specific mutagenic DNA damage through ROS production, rather than CPD formation, in Drosophila larvae. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 887. 10.1016/j.mrgentox.2023.503616.
• Sakasai, R., Wakasugi, M., Matsui, T., Sunatani, Y., Saijo, M., Matsunaga, T. and Iwabuchi, K. (2022). Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair., DNA repair 113, 103318.
• Akahori, R., Takamori, C., Wakasugi, M. and Matsunaga, T. (2022). Mapping of the regions implicated in nuclear localization of multi-functional DNA repair endonuclease XPF-ERCC1., Genes Cells 27, 356-367.
• Kawai, H., Yagyu, F., Terada, A., Matsunaga, T. and Inobe, M. (2021). CD28 confers CD4+ T cells with resistance to cyclosporin A and tacrolimus but to different degrees., Asian Pac J Allergy Immunol., doi:10.12932/AP-270820-0949.
• Saha, L. K., Wakasugi, M., Akter, S., Prasad, R., Wilson, S. H., Shimizu, N., Sasanuma, H., Huang, S. -Y. N., Agama, K., Pommier, Y., Matsunaga, T., Hirota, K., Iwai, S., Nakazawa, Y., Ogi, T. and Takeda, S. (2020). Topoisomerase I-driven repair of UV-induced damage in NER deficient cells., Proc. Natl. Acad. Sci. U.S.A., 117 (25), 14412-14420.
• Kawara, H., Akahori, R., Wakasugi, M., Sancar, A. and Matsunaga, T. (2019). DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair., Biochem. Biophys. Res. Commun. 519, 204-210.
• Tsuda, M., Ogawa, S., Ooka, M., Kobayashi, K., Hirota, K., Wakasugi, M., Matsunaga, T., Sakuma, T., Yamamoto, T., Chikuma, S., Sasanuma, H., Debatisse, M., Doherty, A.J., Fuchs, R.P. and Takeda, S. (2019). PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching. PLoS One 14, e0213383.
• Ueda, M., Matsuura, K., Kawai, H., Wakasugi, M. and Matsunaga, T. (2019). Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase. Genes Cells 24, 284-296.
• Inagaki, F., Momose, M., Maruyama, N., Matsuura, K., Matsunaga, T. and Mukai, C. (2018). Activation of disulfide bond cleavage triggered by hydrophobization and lipophilization of functionalized dihydroasparagusic acid., Org. Biomol. Chem. 16, 4320-4324.
• Sakasai, R., Isono, M., Wakasugi, M., Hashimoto, M., Sunatani, Y., Matsui, T., Shibata, A., Matsunaga, T. and Iwabuchi, K. (2017). Aquarius is required for proper CtIP expression and homologous recombination repair. Scientific Reports 7, 13808.
• Mishima, T., Fukaya, S., Toda, S., Ando, Y., Matsunaga, T. and Inobe, M. (2017). Rapid G0/1 transition and cell cycle progression in CD8+ T cells compared to CD4+ T cells following in vitro stimulation., Microbiol. Immunol. 61, 168-175.
• Mishima, T., Toda, S., Ando, Y., Matsunaga, T. and Inobe, M. (2014). Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression., Cell. Mol. Biol. Lett. 19, 638-648.
• Wakasugi, M., Sasaki, T., Matsumoto, M., Nagaoka, M., Inoue, K., Inobe, M., Horibata, K., Tanaka, K. and Matsunaga, T. (2014). Nucleotide Excision Repair-dependent DNA Double-strand Break Formation and ATM Signaling Activation in Mammalian Quiescent Cells., J. Biol. Chem. 289, 28730-28737.
• Enkhtuya, R., Sato, T., Wakasugi, M., Tuvshintugs, B., Miyata, H., Sakurai, T., Matsunaga, T. and Yoshioka, K. (2014). The scaffold protein JLP plays a key role in regulating ultraviolet B-induced apoptosis in mice., Genes Cells 19, 350-358.
• Zhao, X., Nogawa, A., Matsunaga, T., Takegami, T., Nakagawa, H. and Ishigaki, Y. (2014). Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells., Int. J. Oncol. 44, 222-228.
• Ando, Y., Yasuoka, C., Mishima, T., Ikematsu, T., Uede, T., Matsunaga, T. and Inobe, M. (2014). Concanavalin A-mediated T cell proliferation is regulated by Herpes Virus Entry Mediator costimulatory molecule., In Vitro Cell. Dev. Biol. Anim. 50, 313-320.
• Nishinaga, M., Kurata, R., Onishi, K., Kuriyama, K., Wakasugi, M. and Matsunaga, T. (2012). Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells., Photochem. Photobiol. 88, 356-362.
• Fischer, E.S., Scrima, A., Böhm, K., Matsumoto, S., Lingaraju, G.M., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., Iwai, S., Gut, H., Sugasawa, K. and Thomä , N.H. (2011). The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation., Cell 147, 1024-1039.
• Fisher, L. A., Bessho, M., Wakasugi, M., Matsunaga, T. and Bessho, T. (2011). Role of interaction of XPF with RPA in nucleotide excision repair., J. Mol. Biol. 413, 337-346.
• Uchida, S., Watanabe, N., Kudo, Y., Yoshioka, K., Matsunaga, T., Ishizaka, Y., Nakagama, H., Poon, R. Y. and Yamashita, K. (2011). SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation., J. Cell Sci. 124, 2816-2825.
• Ishigaki, Y., Nagao, A. and Matsunaga, T. (2010). Optimized gene silencing by co-expression of multiple shRNAs in a single vector., Methods Mol. Biol. 623, 109-121.
• Wakasugi, M., Kasashima, H., Fukase, Y., Imura, M., Imai, R., Yamada, S., Cleaver, J. E. and Matsunaga, T. (2009). Physical and functional interaction between DDB and XPA in nucleotide excision repair., Nucleic Acids Res. 37, 516-525.
• Uchida, S., Yoshioka, K., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y., Poon, R. Y. C. and Yamashita K. (2009). Stress-activated MAP kinases JNK and p38 target Cdc25B for degradation., Cancer Res. 69, 6438-6444.
• Matsuura, K., Wakasugi, M., Yamashita, K. and Matsunaga, T. (2008). Cleavage-mediated activation of Chk1 during apoptosis., J. Biol. Chem. 283, 25485-25491.
• Nagao, A., Zhao, X., Takegami, T., Nakagawa, H., Matsui, S., Matsunaga, T. and Ishigaki, Y. (2008). Multiple shRNA expressions in a single plasmid vector improve RNAi against the XPA gene., Biochem. Biophys. Res. Commun. 370, 301-305.
• Hashimoto, S., Egawa, K., Ihn, H., Igarashi, A., Matsunaga, T., Tateishi, S., and Yamaizumi, M. (2008). A new disorder in UV-induced skin cancer with defective DNA repair distinct from xeroderma pigmentosum or Cockayne syndrome., J. Invest. Dermatol. 128, 694-701.
• Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y. and Tanaka, K. (2008). Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair., J. Biol. Chem. 283, 940-950.
  
• Wakasugi, M., Matsuura, K., Nagasawa, A., Fu, D., Shimizu, H., Yamamoto, K., Takeda, S. and Matsunaga, T. (2007). DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells., Biochem. Biophys. Res. Commun. 364, 771-777.
• Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T., Mori, T., Ishizaki, K., Yamashita, K., Inobe, M. and Matsunaga, T. (2007). Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells., J. Cell Sci. 120, 1104-1112.
• Morioka, H., Kurihara, M., Kobayashi, H., Satou, K., Komatsu, Y., Uchida, M., Ohtsuka, E., Torizawa, T., Kato, K., Shimada, I., Matsunaga, T. and Nikaido, O. (2006). DNA-binding properties of the antibody specific for the Dewar photoproduct of thymidylyl-(3'-5')-thymidine., Nucleosides Nucleotides Nucleic Acids 25, 667-679.
• Uchida, S., Kubo, A., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y and Yamashita, K. (2006). Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding., J. Biochem. 139, 761-769.
• Hase, Y., Trung, K. H., Matsunaga, T. and Tanaka, A. (2006). A mutation in the uvi4 gene promotes progression of endo-reduplication and confers increased tolerance towards ultraviolet B light., Plant J. 46, 317-326.
• Tanaka, M., Narumi, I., Funayama, T., Kikuchi, M., Watanabe, H., Matsunaga, T., Nikaido, O. and Yamamoto, K. (2005). Characterization of pathways dependent on the uvde, uvrA1, or uvrA2 gene product for ultraviolet resistance in Deinococcus radiodurans., J. Bacteriol. 187, 3693-3697.
• Mori, M., Yoshida, K., Ishigaki, Y., Matsunaga, T., Nikaido, O., Kameda, K. and Kondo, T. (2005). UV-B protective effect of a polyacylated anthocyanin, HBA, in flower petals of the blue morning glory, Ipomoea tricolor cv. Heavenly Blue., Bioorg. Med. Chem. 13, 2015-2020.
• Thoma, B. S., Wakasugi, M., Christensen, J., Reddy, M. C. and Vasquez, K. M. (2005). Human XPC-HR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks., Nucleic Acids Res. 33, 2993-3001.
• Oyama, M., Wakasugi, M., Hama, T., Hashidume, H., Iwakami, Y., Imai, R., Hoshino, S., Morioka, H., Ishigaki, Y., Nikaido, O. and Matsunaga, T. (2004). Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen., Biochem. Biophys. Res. Commun. 321, 183-191.
• Uchida, S., Kuma, A., Ohtsubo, M., Shimura, M., Hirata, M., Nakagama, H., Matsunaga, T., Ishizaka, Y. and Yamashita K. (2004). Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B., J. Cell Sci. 117, 3011-3020.
• Shiomi, N., Kito, S., Oyama, M., Matsunaga, T., Harada, Y.-N., Ikawa, M., Okabe, M. and Shiomi, T. (2004). Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method., Mol. Cell. Biol. 24, 3712-3719.
• Uchida, S., Ohtsubo, M., Shimura, M., Hirata, M., Nakagama, H., Matsunaga, T., Yoshida, M., Ishizaka, Y. and Yamashita, K. (2004). Nuclear export signal in CDC25B., Biochem. Biophys. Res. Commun. 316, 226-232.
• Lan, L., Rabeya, R. M., Hayashi, T., Nakajima, S., Kanno, S., Takao, M., Matsunaga, T., Yoshino, M., Ichikawa, M., te Riele, H., Tsuchiya, S., Tanaka, K. and Yasui, A. (2004). Functional and physical interactions between ERCC1 and MSH2 for resistance to cis-platinum in mammalian cells., DNA Repair 3, 135-143.
• Inobe, M. and Schwartz, R. H. (2004). CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production, but is not required for tuning T cell reactivity in adaptive tolerance., J. Immunol. 173, 7239-7248.
• Morimoto, J., Inobe, M., Kimura, C., Kon, S., Diao, H., Aoki, M., Miyazaki, T., Denhardt, D. T., Rittling, S. and Uede, T. (2004). Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms., Int. Immunol. 16, 477-488.
• Sakamoto, A., Lan, V. T. T., Hase, Y., Shikazono, N., Matsunaga, T. and Tanaka, A. (2003). Disruption of the AtREV3 gene causes hypersensitivity to ultraviolet B light and γ-rays in Arabidopsis: inplication of the presence of a translesion synthesis mechanism in plants., Plant Cell 15, 2042-2057.
• Hirouchi, T., Nakajima, S., Najrana, T., Tanaka, M., Matsunaga, T., Hidema, J., Teranishi, M., Fujino, T., Kumagai, T. and Yamamoto, K. (2003). A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification., Mol. Gen. Genomics 269, 508-516.
• Fu, D., Wakasugi, M., Ishigaki, Y., Nikaido, O. and Matsunaga, T. (2003). cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein. Gene Genet. Syst. 78, 169-177.
• Spivak, G., Itoh, T., Matsunaga, T., Nikaido, O., Hanawalt, P. and Yamaizumi, M. (2002). Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers., DNA Repair 1, 629-643.
• Wakasugi, M., Kawashima, A., Morioka, H., Linn, S., Sancar, A., Mori, T., Nikaido, O. and Matsunaga, T. (2002). DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair., J. Biol. Chem. 277, 1637-1640.
• Inobe, M., Inobe, I., Adams, G. R., Baldwin, K. M. and Takeda, S. (2002). Effects of microgravity on myogenic factor expressions during postnatal development of rat skeletal muscle., J. Appl. Physiol. 92, 1936-1942.
• Kiyosawa, K., Tanaka, M., Matsunaga, T., Nikaido, O. and Yamamoto, K. (2001). Amplified UvrA protein can ameliorate the ultraviolet sensitivity of an Escherichia coli recA mutant., Mutation Res. 487, 149-156.
• Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., Hanaoka, F., Matsunaga, T., Nikaido, O. and Mori, T. (2001). In situ visualization of ultraviolet light-induced DNA damage repair in locally irradiated human fibroblasts., J. Invest. Dermatol. 117, 1156-1161.
• Wakasugi, M., Shimizu, M., Morioka, H., Linn, S., Nikaido, O. and Matsunaga, T. (2001). Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A., J. Biol. Chem. 276, 15434-15440.
• Tanaka, M., Nakajima, S., Ihara, M., Matsunaga, T., Nikaido, O. and Yamamoto, K. (2001). Effects of photoreactivation of cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts on ultraviolet mutagenesis in SOS-induced repair-deficient Escherichia coli., Mutagenesis 16, 1-6.