研究業績2002年

原著論文

  1. Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon, and Tsuyoshi Yokoi. Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes. Drug Metab. Dispos., 30: 1484-1490 (2002). [PubMed]
  2. Yuichiro Watanabe, Miki Nakajima, and Tsuyoshi Yokoi. Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab. Dispos., 30: 1462-1469 (2002). [PubMed]
  3. Miki Nakajima, Nozomi Sakata, Noriko Ohashi, Toshiyuki Kume, and Tsuyoshi Yokoi. Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes. Drug Metab. Dispos., 30: 1250-1256 (2002). [PubMed]
  4. Kei Takemoto, Hiroshi Yamazaki, Miki Nakajima, and Tsuyoshi Yokoi. Genetoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay. Mutat. Res., 519: 199-204 (2002). [PubMed]
  5. Ryoko Yoshida, Miki Nakajima, Yuki Watanabe, Jun-Tack Kwon, and Tsuyoshi Yokoi. Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism. Br. J. Clin. Pharmacol., 54: 511-517 (2002). [PubMed]
  6. Katsunori Nakamura, Noritaka Ariyoshi, Tsuyoshi Yokoi, Satoru Ohgiya, Michihiro Chida, Kazuo Nagashima, Kazuaki Inoue, Takao Kodama, Noriaki Shimada, and Tetsuya Kamataki. CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability. Biochem Biophys Res Commun. 293: 969-973 (2002). [PubMed]
  7. Takashi Nozawa, Miki Nakajima, Ikumi Tamai, Kumiko Noda, Jun-ichi Nezu, Yoshimichi Sai, Akira Tsuji, and Tsuyoshi Yokoi. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in Japanese population and functional analysis. J. Pharmacol. Exp. Ther. 302: 804-813 (2002). [PubMed]
  8. Masashi Iwanari, Miki Nakajima, Ryoichi Kizu, Kazuichi Hayakawa, Tsuyoshi Yokoi. Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, CYP isoform-, and cell-specific differences. Arch. Toxicol., 76: 287-298 (2002). [PubMed]
  9. Miki Nakajima, Eriko Tanaka, Tomo Kobayashi, Noriko Ohashi, Toshiyuki Kume, and Tsuyoshi Yokoi. Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UGT isoforms. Drug Metab. Dispos., 30: 636-642 (2002). [PubMed]
  10. Hiroshi Yamazaki, Hitomi Iketaki, Ayaka Shibata, Miki Nakajima, and Tsuyoshi Yokoi. Activities of cytochrome P450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/origanic cation transporter. Drug Metab. Pharmacokinet., 17: 47-53 (2002) .[PubMed]
  11. Tomoko Komatsu, Hiroshi Yamazaki, Miki Nakajima and Tsuyoshi Yokoi. Identification of catalase in human liver cytosol as a factor that enhances the phenytoin dihydroxy metabolite formation by human liver microsomes. Biochem. Pharmacol., 63: 2081-2090 (2002). [PubMed]
  12. Miki Nakajima, Kazuhiro Tane, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki and Tsuyoshi Yokoi. Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b5 in the expression system and the differences in the marker activities. J. Pharm. Sci., 91: 952-963 (2002). [PubMed]
  13. Miki Nakajima, Jun-Tack Kwon, Eriko Tanaka and Tsuyoshi Yokoi. High-performance liquid chromatographic assay for N-glucuronidations of nicotine and cotinine in human liver microsomes. Anal. Biochem., 302: 131-135 (2002). [PubMed]
  14. Hiroshi Yamazaki, Mami Nakamura, Tomoko Komatsu, Katsuhiro Ohyama, Satoru Asahi, Noriaki Shimada, F. Peter Guengerich, Tsutomu Shimada, Miki Nakajima and Tsuyoshi Yokoi. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expr. Purif., 24: 329-337 (2002). [PubMed]
  15. Yui Yamamoto, Hiroshi Yamazaki, Tomoko Ikeda, Terumi Watanabe, Haruo Iwabuchi, Miki Nakajima and Tsuyoshi Yokoi. Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxic to HepG2 cells. Drug Metab. Dispos. 30: 155-160 (2002). [PubMed]
  16. Michihiro Chida, Noriaki Ariyoshi, Tsuyoshi Yokoi, Nobuo Nemoto, Minoru Inaba, Moritoshi Kinoshita and Tetsuya Kamataki. New allelic arrangement CYP2D6*36x2 found in Japanese poor metabolizer of debrisoquine. Pharmacogenetics, 12: 659-662 (2002). [PubMed]
  17. Megumi Kubota, Yoko Nakamoto, Kazuo Nakayama, Pailin Ujjin, Soisung Satarug, Taisei Mushiroda, Tsuyoshi Yokoi, Masato Funayama and Tetsuya Kamataki A mutation in the flavin-containing monooxygenase 3 gene and its effects on catalytic activity for N-oxidation of trimethylamine in vitro. Drug Metab. Pharmacokinet., 17 207-213 (2002). [PubMed]

総説

  1. 中島美紀　CYPの遺伝子多型とその解析　臨床検査　446: 31-37 (2002).
  2. 中島美紀　喫煙とCYP2A6の遺伝子多型　医学のあゆみ　201 (9): 675-681 (2002).
  3. 中島美紀, 横井　毅　遺伝子多型と薬物代謝　Medicina　39 (3): 432-435 (2002).
  4. 横井　毅　薬物代謝に関する遺伝子診断の問題点と展望　ファルマシア　38: 403-407 (2002).
  5. 横井　毅　薬物代謝酵素遺伝子の現状ー抗アレルギー薬を中心としてー　Allergy 21st Century 12: 13-16 (2002).
  6. Miki Nakajima, Yukio Kuroiwa, and Tsuyoshi Yokoi. Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6. Drug Metab. Rev., 34: 865-877 (2002).

著書

  1. 山崎浩史、横井　毅　薬物の代謝　「製剤学」　南江堂　(2002)　分担
  2. 横井　毅　創薬サイエンスのすすめ-ポストゲノム時代へのパラダイムシフト-　石川智久、堀江透編　「薬物代謝酵素の遺伝子多型」　共立出版　(2002)　分担