研究業績2004年

原著論文

  1. Tatsuki Fukami, Miki Nakajima, Ryoko Yoshida, Yuki Tsuchiya, Yuto Fujiki, Miki Katoh, Howard L. McLeod and Tsuyoshi Yokoi. A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo. Clin. Pharmacol. Ther., 76: 519-527 (2004). [PubMed]
  2. Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Miho Kataoka, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato and Tsuyoshi Yokoi. Expression of human cytochromes P450 in chimeric mice with humanized liver. Drug Metab. Dispos., 32: 1402-1410 (2004). [PubMed]
  3. Toshiki Tabata, Miki Katoh, Shogo Tokudome, Miki Nakajima and Tsuyoshi Yokoi. Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver. Drug Metab. Dispos., 32: 1103-1110 (2004). [PubMed]
  4. Chise Tateno, Yasumi Yoshizane, Naomi Saito, Miho Kataoka, Rie Utoh, Chihiro Yamasaki, Asato Tachibana, Yoshinori Soeno, Kinji Asahina, Hiroshi Hino, Toshimasa Asahara, Tsuyoshi Yokoi, Toshinori Furukawa, and Katsutoshi Yoshizato. Near-completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol., 32: 901-912 (2004). [PubMed]
  5. Miki Nakajima, Ryoko Yoshida, Tatsuki Fukami, Howard L. McLeod, and Tsuyoshi Yokoi. Novel human CYP2A6 alleles confound gene deletion analysis. FEBS Lett., 569: 75-81 (2004). [PubMed]
  6. Hiroyuki Yamanaka, Miki Nakajima, Kiyoko Nishimura, Ryoko Yoshida, Tatsuki Fukami, Miki Katoh, and Tsuyoshi Yokoi. Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted. Eur. J. Pharm. Sci., 22: 419-425 (2004). [PubMed]
  7. Toshiki Tabata, Miki Katoh, Shogo Tokudome, Masakiyo Hosokawa, Kan Chiba, Miki Nakajima, and Tsuyoshi Yokoi. Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluocytidine formation. Drug Metab. Dispos., 32: 762-767 (2004). [PubMed]
  8. Yuki Tsuchiya, Miki Nakajima, Satoru Kyo, Taro Kanaya, Masaki Inoue, and Tsuyoshi Yokoi. Human CYP1B1 is regulated by estradiol via estrogen receptor. Cancer Res., 64: 3119-3125 (2004). [PubMed]
  9. Kei Takemoto, Miki Nakajima, Yuto Fujiki, Miki Katoh, Frank J Gonzalez, and Tsuyoshi Yokoi. Role of the aryl hydrocarbon receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Toxicol., 78: 309-315 (2004). [PubMed]
  10. Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh, Yusuke Hara, Osamu Tachibana, Junkoh Yamashita, Howard L. McLeod, and Tsuyoshi Yokoi. A novel polymorphism in the promoter region of UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. Pharmacogenetics, 14: 329-332 (2004). [PubMed]
  11. Masuhiro Nishimura, Shinsaku Naito, and Tsuyoshi Yokoi. Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Drug Metab. Pharmacokinet., 19: 135-149 (2004). [PubMed]
  12. Takashi Nozawa, Shigeki Sugiura, Miki Nakajima, Akihiko Goto, Tsuyoshi Yokoi, Jun-ichi Nezu, Akira Tsuji, Ikumi Tamai. Involvement of OATP transporters in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab. Dispos., 32: 291-294 (2004). [PubMed]

総説

  1. 土屋佑樹, 中島美紀, 横井　毅　ヒトCYP1B1の転写調節機構：発癌とエストロゲンのホメオスタシス　生化学　76 (12): 1565-1568 (2004).
  2. 保田国伸, 中島美紀, 横井　毅, 伊澤　修, 宮崎　浩, 大西明弘　降圧薬の内服によりphenocopy現象をきたした１例　臨床薬理 35: 263-264 (2004).
  3. 横井　毅　CYP2D6の遺伝子多型の検出法　臨床検査　48 (2): 163-169 (2004).
  4. 中島美紀, 横井　毅　薬物代謝とファーマコゲノミクス　血液・免疫・腫瘍　9 (2): 35-38 (2004).