Natural Products and Medicinal Chemistry

1. Saito Y, Nishida T, Nakagawa-Goto K, Spiromeroterpenoids from the higher plants (invited review) Chem. Pharm. Bull., 2025, 73, 138-155. DOI:10.1248/cpb.c24-00733

2. Watanabe K, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K, Two New Halimanes with a γ-Lactone and a Tricyclic Diterpene from Croton argyratus. Chem. Pharm. Bull., 2025, 73, 162-167. DOI:10.1248/cpb.c24-00734

1. Koga N, Kawashima K, Ito C, Nishida T, Fukuyoshi S, Saito Y, Miyake K, Amuti S, Abdul R, Ahmad N, Alam G, Tanaka N, Nakagawa-Goto K.* Spiro-meroterpenoids, Syzygioblanes D-H, isolated from Indonesian medicinal plant Syzygium oblanceolatum, J. Nat. Prod., 2024, 87, 2872-2880. DOI:10.1021/acs.jnatprod.4c01154

2. Tabei T, Nakagawa-Goto K, Saito Y.* Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules, Chem Commun., 2024, 60, 14252-14255. DOI: 10.1039/D4CC05370B

3. Cheng Y-T, Chang D-M, Tung Y-C, Hsiao Y-W, Nakagawa-Goto K, Shyur LF. Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis, Phytomedicine 2024, 135, 156226. DOI: 10.1016/j.phymed.2024.156226

4. Kouno H, Amuti S, Saito Y, Fukuyoshi S, Miyake K, Goto M, Newman DJ, O’keefe BR., Lee, KH, Nakagawa-Goto K.* Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis, J. Nat. Prod. 2024, 87, 1763-1777. DOI: 10.1021/acs.jnatprod.4c00313

5. Koga N, Saito Y, Miyake K, Amuti S, Fukuyoshi S, Yoshida S, Sato S, Yamada Y, Ikeda A, Adachi N, Kawasaki M, Takasu A, Aramaki S, Senda T, Rahim A, Najib A, Alam G, Tanaka N, Nakagawa-Goto K.* Cyclic sesquiterpene-flavanone [4+2] hybrids, Syzygioblanes A-C, found in an Indonesian traditional medicine, 'Jampu Salo' (Syzygium oblanceolatum), Org. Lett. 2024, 26,4302-4307. DOI:10.1021/acs.orglett.4c01248

6. Maeda S, Nakayama W, Saito Y, Sagano M, Goto M, Nakagawa-Goto K.* Total Synthesis of a TNBC-selective Cytotoxic Bromo Nor-eremophilane, PC-A, and Its Preliminary Structure-activity Relationships, J. Nat. Prod. 2024, 87, 861-868. DOI:10.1021/acs.jnatprod.3c01075

7. Amuti S, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O’keefe BR., Lee, KH, Nakagawa-Goto K.* Unusual Vilasinin-Class Limonoids from Trichilia rubescens, Molecules, 2024, 29, 651. DOI:10.3390/molecules29030651

8. Kobayashi A, Saito Y, Miyake K, Fukuyoshi S, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K.* Caged xanthones and biphenyls isolated from a tropical plant, Garcinia lateriflora, J. Nat. Prod. 2024, 87, 266-275. DOI:10.1021/acs.jnatprod.3c00934

1. Yasir B, Rahim A, Lallo S, Saito Y, Nakagawa-Goto K, Roman A, Alam G. Cytotoxicity activity, metabolite profiling, and isolation compound from crude hexane extract of Cleome rutidospermae, Aisan Pac J Cancer Prev 2023, 24, 3345-3352. DOI:10.31557/APJCP.2023.24.10.3345

2. Shimoi R, Saito Y, Miura Y, Nakagawa-Goto K.* Total synthesis of waltherinone A, a qunoline alkaloids fused with oxabicyclo[3.2.1]octane, Org. Lett. 2023, 25, 4755-4758. DOI:10.1021/acs.orglett.3c01837

3. Shimada R, Naito R, Toriumi R, Nakagawa R, Aoyama S, Kamijima T, Kano H, Kadomoto S, Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Nakata H, Saito Y, Nakagawa-Goto K, Mizokami A. Novel α-trifluoromethyl chalcone exerts antitumor effects against prostate cancer cells, Anticancer Res. 2023, 432433-2444. DOI: 10.21873/anticanres.16411

4. Rahim A, Amuti S, Najib A, Miyake K, Saito Y, Nakagawa-Goto K,* A new bis-indole alkaloid, spermaocymine A, and an anthraquinone from Spermacoce ocymoides, Chem. Pharm. Bull. 2023, 71, 380-384. DOI: 10.1248/cpb.c23-00005

5. Kano H, Izumi K, Hiratsuka K, Toriumi R, Nakagawa R, Aoyama S, Kamijima T, Shimada T, Naito R, Kadomoto S, Iwamoto H, Yaegashi H, Kawaguchi S, Nohara T, Shigehara K, Kadono Y, Saito Y, Nakagawa-Goto K, Yoshioka K, Nakata H, Lin W-J, Mizokami A, Suppression of androgen receptor signalin induces prostate cancer migration via activation of the CCL20?CCR6 axis, Cancer Science, 2023, 114, 1479-1490．DOI: 10.1111/cas.15683

6. Cheng YT, Nakagawa-Goto K, Lee KH, Shyur LF. MicroRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones, Antioxid. Redox Signal. 2023, 38, 198-214. DOI: 10.1089/ars.2021.0251